News & Publications2026-09-14T14:37:34+00:00

NEWS

PUBLICATIONS

  • Gp120-Activated Allogeneic Regulatory T cells for Prevention of Graft-versus-Host-Disease – a First-in-Human Trial. Transplant Cell Ther [[Tuettenberg A, Ruhnke L, Schlöder J, Zimmer N, Rücker C, Wehler D, Epp K, Janson D, Wetzko K, Reicherts C, Bornhäuser M, Zeiser R, Stelljes M, Meyer RG, Wermke M, Wagner-Drouet EM, Jonuleit H.] (Clinical Trial)

  • Impaired PTEN expression in T cells drives resistance to Treg-3 mediated immune regulation in multiple sclerosis. Cells [Schlöder J, Trinschek B, Luessi F, Jonuleit H.]

  • Boosting regulatory T cell function for the treatment of autoimmune diseases – That’s only half the battle! Front. Immunol. [Schlöder J, Shahneh F, Schneider FJ, Wieschendorf B.] (Review article)

  • Using immuno-PET imaging to monitor kinetics of T cell-mediated inflammation and treatment efficiency in a humanized mouse model for GvHD. Eur J Nucl Med Mol Imaging. [Pektor S, Schlöder J, Klasen B, Bausbacher N, Wagner DC, Schreckenberger M, Grabbe S, Jonuleit H, Miederer M.]

  • Dimethyl Fumarate Therapy Significantly Improves the Responsiveness of T Cells in Multiple Sclerosis Patients for Immunoregulation by Regulatory T Cells. International Journal of Molecular Sciences. [Schlöder J, Berges C, Luessi F, Jonuleit H.]
  • Novel Concept of CD4-Mediated Activation of Regulatory T Cells for the Treatment of Graft-Versus-Host Disease. Front Immunol. [Schlöder J, Berges C, Tuettenberg A, Jonuleit H.]

  • Editorial: Current Concepts of Cellular and Biological Drugs to Modulate Regulatory T Cell Activity in the Clinic. Front Immunol. [Jonuleit H, Bopp T.]
  • Kinome Profiling of Regulatory T Cells: A Closer Look into a Complex Intracellular Network. PLoS One. [Tuettenberg A, Hahn SA, Mazur J, Gerhold-Ay A, Scholma J, Marg I, Ulges A, Satoh K, Bopp T, Joore J, Jonuleit H.]

  • Interferon-Beta Therapy of Multiple Sclerosis Patients Improves the Responsiveness of T Cells for Immune Suppression by Regulatory T Cells. Int J Mol Sci. [Trinschek B, Luessi F, Gross CC, Wiendl H, Jonuleit H.]

  •  Kinetics of IL-6 Production Defines T Effector Cell Responsiveness to Regulatory T Cells in Multiple Sclerosis. PLoS ONE. [Trinschek B, Luessi F, Haas J, Wildemann B, Zipp F, et al.]
  • In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling. Sci Transl Med. [Schneider A, Long SA, Cerosaletti K, Ni CT, Samuels P, Kita M, Buckner JH.]

  • Boosting regulatory T cell function by CD4 stimulation enters the clinic. Front Immunol. [Becker C, Bopp T, Jonuleit H.]
  • CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease. J Allergy Clin Immunol. [Martin H, Reuter S, Dehzad N, Heinz A, Bellinghausen I, Saloga J, Haasler I, Korn S, Jonuleit H, Buhl R, Becker C, Taube C.]

  • Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells. Blood. [Becker C, Taube C, Bopp T, Becker C, Michel K, Kubach J, Reuter S, Dehzad N, Neurath MF, Reifenberg K, Schneider FJ, Schmitt E, Jonuleit H.]
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